Genetic polymorphisms of interleukin-22 in patients with ulcerative colitis

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Association of the interleukin-22 genetic polymorphisms with ulcerative colitis

BACKGROUND Interleukin-22 (IL-22) is a member of the IL-10 family of anti-inflammatory cytokines that mediates epithelial immunity. IL-22 expression was found to be increased in patients with ulcerative colitis (UC). Whether genetic polymorphisms of IL-22 also influence UC risk is still unknown. The purpose of this study was to investigate the association between the IL-22 gene polymorphisms (-...

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Background: Patients with ulcerative colitis are at increased risk of inflammation. Interleukin 23 (IL-23) is a newly identified cytokine with increased expression in inflamed biopsies of colon mucosa in patients with Crohn's disease; however, there is inconsistent evidence on its role in ulcerative colitis. Objective: We aimed to compare serum IL-23 level in patients with ulcerative colitis an...

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interleukin-17 serum levels and tlr4 polymorphisms in ulcerative colitis

background: inflammatory bowel disease, an autoimmune disease, has two clinical manifestations including crohn’s disease and ulcerative colitis (uc). il-17 has been the target of intensive research in autoimmune diseases. the influence of toll like receptor 4 (tlr-4) gene polymorphisms on il-17 production has also been revealed in uc patients and tissue inflammation in mice. objectives: to inve...

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ژورنال

عنوان ژورنال: Revista de Gastroenterología de México (English Edition)

سال: 2016

ISSN: 2255-534X

DOI: 10.1016/j.rgmxen.2016.02.006